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→Contrast-induced nephropathy: When it matters
'''Washout''' is where tissue loads radiocontrast during arterial phase, but then returns to a rather hypodense state in venous or later phases. This is a property of for example [[hepatocellular carcinoma]] as compared to the rest of the liver parenchyma.<ref name="ChoiLee2014">{{cite journal|last1=Choi|first1=Jin-Young|last2=Lee|first2=Jeong-Min|last3=Sirlin|first3=Claude B.|title=CT and MR Imaging Diagnosis and Staging of Hepatocellular Carcinoma: Part II. Extracellular Agents, Hepatobiliary Agents, and Ancillary Imaging Features|journal=Radiology|volume=273|issue=1|year=2014|pages=30–50|issn=0033-8419|doi=10.1148/radiol.14132362|pmc=4263770|pmid=25247563}}</ref>
==Contrast-induced nephropathyLow renal function==Decreased renal function and several other conditions increase the risk of '''contrast-induced nephropathy''', which is a potentially lethal renal injury to the kidney following intravenous radiocontrast.<ref name="RudnickFeldman2008">{{cite journal|last1=Rudnick|first1=M.|last2=Feldman|first2=H.|title=Contrast-Induced Nephropathy: What Are the True Clinical Consequences?|journal=Clinical Journal of the American Society of Nephrology|volume=3|issue=1|year=2008|pages=263–272|issn=1555-9041|doi=10.2215/CJN.03690907}}</ref> ===When it matters===According to European guidelines, the main risk factors of ''contrast-induced nephropathy'':<ref name="NymanAhlkvist2018">{{cite journal|last1=Nyman|first1=Ulf|last2=Ahlkvist|first2=Joanna|last3=Aspelin|first3=Peter|last4=Brismar|first4=Torkel|last5=Frid|first5=Anders|last6=Hellström|first6=Mikael|last7=Liss|first7=Per|last8=Sterner|first8=Gunnar|last9=Leander|first9=Peter|title=Preventing contrast medium-induced acute kidney injury|journal=European Radiology|year=2018|issn=0938-7994|doi=10.1007/s00330-018-5678-6}}</ref>*Estimated glomerular filtration rate (eGFR) of less than 30 ml/min/1.73 m2 before intra-venous or intra-arterial radiocontrast administration with second-pass renal exposure (passing lungs or other tissues before the kidneys).*eGFR of less than 45 ml/min/1.73 m<sup>2</sup> before intra-arterial administration with first-pass renal exposure or in ICU patients*Known or suspected acute renal failure*Large doses of radiocontrast given IA with first-pass renal exposure*Multiple radiocontrast injections within 48-72 h
[[File:Contrast CT in low GFR.png|thumb|250px|center|In case of low GFR, the procedure depends on whether the dose that can be given is larger or less than the needed dose.]]
