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In some emergent conditions such as [[CT of aortic aneurysm]] with suspected rupture, the need for contrast is greater than the risk of contrast-induced nephropathy.
For the rest of the investigations, evidence suggests that contrast doses should be limited to a ratio of grams of iodine to glomerular filtration rate (I<sub>gram</sub> / GFR<sub>ml/min</sub>) of a maximum of 1.<ref name="KeaneyHannon2013">{{cite journal|last1=Keaney|first1=J. J.|last2=Hannon|first2=C. M.|last3=Murray|first3=P. T.|title=Contrast-induced acute kidney injury: how much contrast is safe?|journal=Nephrology Dialysis Transplantation|volume=28|issue=6|year=2013|pages=1376–1383|issn=0931-0509|doi=10.1093/ndt/gfs602}}</ref> The local A Swedish practice at NU Hospital Group has is to have a I<sub>gram</sub>/GFR ratio of maximum 0.7 in patients with GFR ≥45 ml/min. <ref name=NU>{{NU Hospital Group}}</ref> It recommends a ratio of maximum 0.5 if GFR is lower, or in the presence of risk factors.<ref name=NU/>
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|+ Volume for various I<sub>gram</sub> / GFR<sub>ml/min</sub> ratios
