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The main sign Look for signs of a urinary bladder tumor is wall tumors, which mainly are:*'''Wall thickening''', especially when nodular or irregular.<ref name="RamanFishman2014"/> However, the anterior wall is frequently thickened in a normal underdistended bladder.<ref name="RamanFishman2014"/> Also, diffuse bladder wall thickening rarely represents malignancy.<ref name="RamanFishman2014"/> Look both at images 40 seconds after IV contrast and with contrast-containing bladder lumen, since that contrast may both demarcate a tumor as well as obscure one by beam-hardening artifacts.<ref name="RamanFishman2014"/>:*'''Enlarged lymph nodes''', which, may be metastases. Generalized lymphadenopathy may indicate lymphoma, and in such cases tumors in the urinary system may be lymphomas as well.<ref name="RamanFishman2014"/>