CT with IV contrast

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A woman undergoing CT with IV contrast.

Contrast CT is CT scan using radiocontrast, and in Radlines it refers to a CT scan using IV contrast except otherwise noted.

Bolus tracking is where a specified location within the circulatory system is monitored during IV contrast infusion, and the timing of the main imaging is counted from when the contrast reaches this location (sufficiently to achieve a specified threshold).

Washout is where tissue loads radiocontrast during arterial phase, but then returns to a rather hypodense state in venous or later phases. This is a property of for example hepatocellular carcinoma as compared to the rest of the liver parenchyma.[1]

Phases

Depending on the purpose of the investigation, there are standardized protocols for time intervals between intravenous radiocontrast administration and image acquisition, in order to visualize the dynamics of contrast enhancements in different organs and tissues.[2] The main phases thereof are as follows:[3]

Phase Time from injection[3] Time from bolus tracking in proximal aorta[3] Targeted structures and findings[3]
Non-enhanced CT (NECT) - -
Pulmonary arterial phase 6-13 sec[4] -
Pulmonary venous phase 17-24 sec[4] -
Early systemic arterial phase 15-20 sec immediately
  • Arteries, without enhancement of organs and other soft tissues.
Late systemicarterial phase
Sometimes also called "arterial phase" or "early venous portal phase"
35-40 sec 15-20 sec
  • All structures that get their blood supply from the arteries have optimal enhancement.
  • Some enhancement of the portal vein
Pancreatic phase 30[5] or 40[6] - 50[6] sec 20-30 sec
Hepatic (most accurate) or late portal phase 70-80 sec 50-60 sec
  • Liver parenchyma enhances through portal vein supply, normally with some enhancement of the hepatic veins.
Nephrogenic phase 100 sec 80 sec
  • All of the renal parenchyma enhances, including the medulla, allowing detection of small renal cell carcinomas
Systemic venous phase 180 sec[7] 160 sec
Delayed phase
Sometimes called "wash out phase" or "equilibrium phase"
6[3]-15[7] minutes 6[3]-15[7] minutes
  • Disappearance of contrast in all abdominal structures except for tissue with fibrosis, which appears more radiodense.

Gastrointestinal contrast

Rectally administered contrast is indicated in cases where a suspicion remains of penetrating trauma to the colon where an initial CT shows no reason for immediate surgery.[8]

References

  1. Choi, Jin-Young; Lee, Jeong-Min; Sirlin, Claude B. (2014). "CT and MR Imaging Diagnosis and Staging of Hepatocellular Carcinoma: Part II. Extracellular Agents, Hepatobiliary Agents, and Ancillary Imaging Features ". Radiology 273 (1): 30–50. doi:10.1148/radiol.14132362. ISSN 0033-8419. PMID 25247563. 
  2. Bae, Kyongtae T. (2010). "Intravenous Contrast Medium Administration and Scan Timing at CT: Considerations and Approaches ". Radiology 256 (1): 32–61. doi:10.1148/radiol.10090908. ISSN 0033-8419. 
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Robin Smithuis. CT contrast injection and protocols. Radiology Assistant. Retrieved on 2017-12-13.
  4. 4.0 4.1 Page 584 in: Ákos Jobbágy (2012). 5th European Conference of the International Federation for Medical and Biological Engineering 14 - 18 September 2011, Budapest, Hungary. Volume 37 of IFMBE Proceedings . Springer Science & Business Media. ISBN 9783642235085. 
  5. Raman SP, Fishman EK (2012). "Advances in CT Imaging of GI Malignancies. ". Gastrointest Cancer Res 5 (3 Suppl 1): S4-9. PMID 22876336. PMC: 3413036. Archived from the original. . 
  6. 6.0 6.1 6.2 Otto van Delden and Robin Smithuis. Pancreas - Carcinoma. Radiology Assistant. Retrieved on 2017-12-15.
  7. 7.0 7.1 7.2 7.3 Dongqing Wang (2013). Selected Topics on Computed Tomography . ISBN 9789535111023.  License: CC-BY-3.0. Chapter 1: "Computed Tomography in Abdominal Imaging: How to Gain Maximum Diagnostic Information at the Lowest Radiation Dose" by Kristie Guite, Louis Hinshaw and Fred Lee. DOI: 10.5772/55903
  8. Stephen Ledbetter and Robin Smithuis (2007-08-02). Acute Abdomen - Role of CT in Trauma. Radiopaedia.