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→Indication: +D-dimer
[[File:Swedish algorithm of deep vein thrombosis.png|thumb|center|Swedish algorithm.<ref>{{cite web|title=Djup ventrombos, DVT|website=Internetmedicin|author=Docent Henry Eriksson, Med dr, överläkare Fariba Baghaei, Specialistläkare Valerie Bockisch, Professor emerita Margareta Hellgren, Docent Leif Lapidus, Överläkare Per-Åke Moström, Med dr, Överläkare Vladimir Radulovic, Överläkare Lennart Stigendal|url=https://www.internetmedicin.se/page.aspx?id=1206}} Updated 2017-06-11</ref>]]
The threshold for normal versus high D-dimer is generally 500 ng/mL or 0.5 mg/L.<ref>{{cite journal |vauthors=Ageno W, Finazzi S, Steidl L, etal |title=Plasma measurement of D-dimer levels for the early diagnosis of ischemic stroke subtypes |journal=Archives of Internal Medicine |volume=162 |issue=22 |pages=2589–93 |year=2002 |pmid=12456231 |url=http://archinte.jamanetwork.com/article.aspx?volume=162&page=2589 |doi=10.1001/archinte.162.22.2589}}</ref> In pregnant or elderly patients, corresponding D-dimer ranges need to be used.<ref group="notes">
;Pregnant patients
Upper limit of reference range for D-dimer:
{|class="wikitable"
! Units !! Nonpregnant <br>adult !! First trimester !! Second trimester !! Third trimester
|-
| mg/L or µg/mL || < 0.5 || < 0.95 || < 1.29 || < 1.7
|-
| µg/L or ng/mL || < 500 || < 950 || < 1290 || < 1700
|-
| nmol/L || < 2.7 || < 5.2 || < 7.1 || < 9.3
|}
<font size=1>Reference: [http://www.perinatology.com/Reference/Reference%20Ranges/D-Dimer.htm Reference Values During Pregnancy] at perinatology.com. Retrieved October 2014.</font>
;Elderly patients:
Patient’s age in years × 10 µg/L (or x 0.056 nmol/L) for patients aged over 50 years for the suspicion of venous thromboembolism (VTE).
<br><font size=1>References:
*{{cite journal |vauthors=Urban K, Kirley K, Stevermer JJ |title=PURLs: It's time to use an age-based approach to D-dimer |journal=J Fam Pract |volume=63 |issue=3 |pages=155–8 |date=March 2014 |pmid=24701602 |pmc=4042909 |doi= |url=}}
*{{cite journal |last1=Raja |first1=Ali S. |last2=Greenberg |first2=Jeffrey O. |last3=Qaseem |first3=Amir |last4=Denberg |first4=Thomas D. |last5=Fitterman |first5=Nick |last6=Schuur |first6=Jeremiah D. |title=Evaluation of Patients With Suspected Acute Pulmonary Embolism: Best Practice Advice From the Clinical Guidelines Committee of the American College of Physicians |journal=Annals of Internal Medicine |date=29 September 2015 |volume=163 |issue=9 |pages=701 |doi=10.7326/M14-1772 |pmid=26414967}}</font></ref>
In certain circumstances, it may also be indicated in suspected pulmonary embolism, see '''[[pulmonary embolism]]'''.
