In a normal case, the contrast flows straight out from the catheter.<ref name=Helsingborg/> Contrast flowing at a skewed angle compared to the catheter is regarded to be a suspected fibrin sheath.<ref name=Helsingborg/>
A definite fibrin sheath is visualized as contrast flowing backwards around the catheter, looking like a thickening of the distal part, before exiting at a more proximal part of the catheter. Preferably note the distance between the catheter tip and the exiting point, and whether it is in a different vein(such as the brachiocephalic vein).
[[File:Central venous catheter with a fibrin sheath.jpg|thumb|center|The fibrin sheath is indirectly seen in these images before and after radiocontrast infusion, as the radiocontrast collects around the catheter.]]